“Life is always beautiful,exciting and valuable”, answered Ursula Broermann, a woman with late-stage ALS and who was almost completely paralyzed, to a question from a journalist why she had chosen for artificial respiration.  The journalist assumed that people who are locked-in would want to die, but Ursula seemed happy to be alive.

The classical locked-in state is characterized by total immobility except for vertical eye movements or blinking. Incomplete (or residual) LIS permits remnants of voluntary motion and total (or complete) LIS consists of complete immobility including all eye movements combined with preserved consciousness.

The Locked-in Lab, led by Dr. Femke Nijboer, looks at the locked-in syndrome and related disorders (SMA, ALS, SCI)  from different angles.

  • Quality of life and coping with LIS, ALS or related disorders
  • Medical decisions and end-of-life decisions in LIS and ALS
  • Neuroethics
  • Assistive technologies
  • Social participation
  • Brain-Computer Interfacing

We often find out that being lock-in, may also mean you are locked-out. So, we try to come up with innovative technologies to unlock people and strategies to include people in society.

locked-in syndrome
Dr. Femke Nijboer and Sun-Mi Venema, a Dutch woman living with locked-in syndrome

Master student

Anke van den Akker

The effect of body position on rest EEG

Master student

The effect of body posture on Event-Related Potentials.

Evelien Lageweg

Master student

The effect of macro- and microgravity on sensorimotor rhythms and Brain-Computer Interface performance. Team Brainfly. A project in cooperation with the European Space Agency

Rebecca Mourits

Master student

The effect of gravity on the P300 event-related potential. Team BrainFly. A project in cooperation with the European Space Agency

Roos Amersfoort

Master student

Locked-in syndrome: a literature review of quality of life

Master student

End-users’ preferences in strategies to control a Brain-Computer interface

Master student

A literature review of Brain-Computer Interface Technology for Aerospace

Pia Michel

Pia Michel

Intern BrainFly project